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Clinical features

Dysregulation of breathing and autonomic homeostasis

Autonomic nervous system is the part of the nervous system that controls involuntary actions, such as the beating of the heart and the widening or narrowing of the blood vessels.

Hyperventilation

Forceful breathing.

Apnea

Severe pauses in breathing.

Abnormal cardiorespiratory coupling

More severe during wakefulness.

Abnormal sweating

Decreased heart rate variability

Cold extremities

A consequence of altered autonomic control.

Sleep abnormalities

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